2022년 2월 연구원 논문
김지현 선임연구원 (알레르기및임상면역연구소)
Serum amyloid A promotes emphysema by triggering the reciprocal activation of neutrophils and ILC3s
Clin Transl Med.
Chronic obstructive pulmonary disease (COPD) is a group of irreversible lung diseases that include emphysema and chronic bronchiolitis. 1 Many studies have shown that COPD is due to adaptive immune responses, particularly CD8+ and CD4+ T cells 2 , 3 ; however, the role(s) that innate immune cells such as innate lymphoid cells (ILCs) and granulocytes play in the pathogenesis of emphysema and COPD is largely unknown. Here, we show that neutrophils, and particularly type 3 innate lymphoid cells (ILC3s), play a key role in the development of COPD with the emphysema phenotype.