2024년 12월 연구원 논문
할무라토바로자 연수연구원 (허혈저산소질환연구소)
NRP1 antagonism as a novel therapeutic target in nasal polypsof patients with chronic rhinosinusitis
Allergy
Background: Neuropilin-1 (NRP1) is expressed on the surface epithelium of respir-
atory tract and immune cells, demonstrating its possible function in regulating the
immune response in airway disease. However, its role in patient with chronic rhinosi-
nusitis (CRS) remains unknown. This study aimed to elucidate the role of NRP1 in CRS
with nasal polyps (CRSwNP).
Methods: Sinonasal biopsy specimens were immunohistochemically stained to inves-
tigate NRP1 expression. Double immunofluorescence, immunoblotting, and real-time
polymerase chain reaction were performed to evaluate NRP1 in primary human nasal
epithelial cells (hNECs). An NRP1 inhibitor was administered to a murine nasal polyp
(NP) model.
Results: NRP1 was highly expressed in the epithelium in patients with CRSwNP com-
pared to nasal tissue from controls and CRS without NP patients. NRP1 and vascu-
lar endothelial growth factor were upregulated in hNECs under hypoxia. Treatment
