신경과학연구소 해외연자 특별 세미나를 개최하게 되어 안내드립니다. 
일시: 11월 27일 수요일 오후 4시
연자: Mark Andermann (Harvard Medical School)
제목: Estimation of current and future physiological states in insular cortex
장소: 연구관 생리학교실 708호 세미나실

Abstract:
Interoception, the sense of internal bodily signals, is essential for physiological homeostasis, cognition, and emotions. Studies in humans highlight the importance of insular cortex (InsCtx) for interoception, but the underlying activity patterns and circuit mechanisms remain unclear. We performed cellular imaging across natural and artificial states of hunger and thirst. InsCtx neurons selectively responded to cues predicting food/water, but also showed gradual changes in ongoing activity reflecting physiological state transitions. During hunger/thirst, food/water cues rapidly and transiently shifted the pattern of InsCtx population activity towards representations of future satiety. In sated/quenched mice, artificial activation of hypothalamic neurons that drive hunger/thirst restored selective behavioral and InsCtx responses to food/water cues, but did not restore InsCtx representations of physiological state. Together with circuit-mapping experiments, these data suggest that InsCtx integrates visceral-sensory inputs regarding current physiological state with hypothalamus-gated limbic inputs signaling upcoming ingestion of food/water to compute a prediction of future physiological state.