Professor for Neurobiology, Department of Neurophysiology, Charité Universitätsmedizin Berlin
- 제목 : Should I stop or should I go? Exquisite regulation of neurotransmitter release at mammalian synapses
- 일시 :  2023년 4월 25일 (화) 오전 11시
- 장소 :  서울의대 연건캠퍼스 교육관 117호 강의실 
- 주최 :  서울대학교 의학연구원 신경과학연구소

Abstract
Neurons perform numerous and complex computations as they communicate with each other via neurotransmitters. The presynaptic terminal is a specialized structure, storing neurotransmitters in vesicles and ensuring their release by orchestrating signals that connect incoming action potentials with the vesicle release machinery. Syntaxin-1 is part of the presynaptic SNARE complex that participates in the transduction of incoming action potential into the fusion of synaptic vesicles with the presynaptic plasma membrane. The underlying mechanisms of how the SNARE complex and other accessory proteins mediate the multiple steps preparing synaptic vesicles for fusion and executing the fusion itself are intensely researched. I will present our recent analysis of syntaxin-1 function in mammal neurons through the use of electrophysiological and imaging methods, as well as the use of advanced electron microscopic techniques. We discovered two novel mechanisms including post translational modification that regulate various aspects of evoked and spontaneous release.