이번 초청연자는 IP3 receptor를 처음 발견하신 ShanghaiTech Univ.의 Katsuhiko Mikoshiba 교수님이십니다.
<해외연자 초청 세미나>
∙ 연제 : Endoplasmic reticulum-IP3R/Ca2+ channel in physiological and pathophysiological condition
∙ 연자 : Katsuhiko Mikoshiba, MD PhD. 
             (Professor, PI Cell Calcium Signaling Lab, ShanghaiTech University)
∙ 일시 : 2024년 5월 22일(수) 오후 3시
∙ 장소 : 생리학교실 회의실(연구관 708호)
- 주관 : 신경과학연구소,    
Abstract:
Mikoshiba established novel concepts of endoplasmic reticulum (ER)-resident IP3R/channel which he discovered from the ataxic mice cerebellum: He established that it is a Ca2+ oscillator and plays a role in development and brain function. It is a causal gene for human spinocerebellar ataxia 15/16 29, Gillespie Syndrome, ataxic cerebral palsy, pontocerebellar hypoplasia, and human exocrine secretion (sweat) deficit. It is a Ca2+ channel with huge (1,252kDa) signaling hub for disease-associated molecules (anti-/pro-apoptotic proteins, huntingtin, ataxin, caspase 3 and chaperones). It is a key integrator for sensing ER stress response to protect from neurodegenerative disorders. (Google citation 85,870 h-index. 140 D-index 145)